A Presentation by Dr. Lynn Zechiedrich: MiniVectors™ – A New Platform Technology 
for DNA Discovery and Transfection

Dr. Lynn Zechiedrich, CEO of Twister Biotech, Professor at Baylor College of Medicine, and internationally renowned authority on DNA structure and topology speaks about MiniVectors, a new class of minimized circular DNA vectors. Containing only a promoter and open reading frame, these DNA vectors are devoid of the large size and bacterial sequences that hamper plasmid DNA as a viable non-viral gene therapy vector.

Dr. Zechiedrich describes experiments that have demonstrated MiniVectors as a safe and effective platform for getting DNA into “difficult-to-transfect” cells, such as primary and stem cells; and explains how these tiny, twisted up circles allow the first explorations of active DNA, and proteins or drugs that act on DNA.


Irobalieva RN, Fogg JM, Catanese DJ, Sutthibutpong T, Chen M, Barker AK, Ludtke SJ, Harris SA, Schmid MF, Chiu W, Zechiedrich L. (2015) Structural Diversity of supercoiled DNA. Nature Comm [Epub ahead of print]. [article]